Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer
- García-Cremades Mira, María
- Iñaki F. Trocóniz Zuzendaria
Defentsa unibertsitatea: Universidad de Navarra
Fecha de defensa: 2017(e)ko iraila-(a)k 29
- José Martínez Lanao Presidentea
- Maria Jesus Garrido Cid Idazkaria
- Sonya Catherine Tate Kidea
- Victor Mangas Sanjuan Kidea
- Julen Oyarzabal Santamarina Kidea
Mota: Tesia
Laburpena
This thesis performs a retrospective evaluation of data generated for the cytotoxic/cytostatic antimetabolite drug gemcitabine along the different phases of drug development. Using these data, and through data analysis and simulations-based translational exercise, a model-based framework in oncology, relating in vitro and in vivo pre-clinical pharmacokinetic (PK) and tumour size (TS) information, with response outcome obtained in clinical trials, has been developed.