Efecto del clorhidrato de mianserina sobre preparaciones de órgano aislado de cobaya y de rata "in vitro"
- Treceño Lobato, C.
- Morán Benito, Asunción
- Velasco Martín, Alfonso
ISSN: 1139-8264
Year of publication: 2008
Volume: 11
Issue: 3
Pages: 101-103
Type: Article
More publications in: Revista española de investigaciones quirúrgicas
Abstract
OBJETIVE. Study the modifications produced by mianserin in the responses of isolated guinea-pig to acetylcholine and histamine, rat vas deferens to noradrenalinee and rat uterus to histamine. MATERIAL AND METHODS. Guinea-Pig ileum incubated in Tyrode solution were used. Dose-effect curves to acetylcholine and histamine were made in absence and in the presence of mianserin. Rat vas deferens incubated in Krebs-Henseleit solution were used. Dose-effect curves to noradrenaline were made in absence and in the presence of mianserin. Uterus of rat incubated in Jalon solution were used. Dose-effect curves to histamine were made in absence and in the presence of mianserin, pA2 was calculated. RESULTS. Mianserin behave as antagonist of acethylcholine, histamine and noradrenaline. Conclusions: Mianserin acts as few unspecific membrane stabilizer.