Mediastinal paraganglioma detected by 111in-Pentetreotide scintigraphy and SPECT/TC. A case report

  1. DÍAZ-GONZÁLEZ, Luis Gonzaga 1
  2. PÉREZ-LÓPEZ, Berta 2
  3. FRANCO-RODRÍGUEZ, Yoana 2
  4. MUÑOZ-HERRERA, Ángel 2
  5. TAMAYO-ALONSO, Pilar 2
  1. 1 Nuclear Medicine Department. Hospital Universitario de Salamanca.
  2. 2 Hospital Universitario de Salamanca
    info

    Hospital Universitario de Salamanca

    Salamanca, España

    ROR https://ror.org/0131vfw26

Aldizkaria:
Revista ORL

ISSN: 2444-7986,  2444-7986

Argitalpen urtea: 2017

Alea: 8

Alea: 4

Orrialdeak: 249-252

Mota: Artikulua

DOI: 10.14201/ORL201784.15783 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Beste argitalpen batzuk: Revista ORL

Garapen Iraunkorreko Helburuak

Laburpena

Introduction: Mediastinal paragangliomas are low incidence tumors that arise from neural crest. Its diferential diagnosis include several malignant diseases, so its correct characterization is mandatory for an adecuate therapeutic management. 111In-Pentetreotide scintigraphy/SPECT-CT can detect paraganglioma, mainly in those cases of atypical or unsuspected location, and may have a significant role in follow-up of those patients diagnosed with multifocal and familiar paraganglioma. Case: Here we report a case of an extremely rare middle mediastinal paraganglioma, detected by scintigraphy and SPECT-CT with 111In-Pentetreotide in a patient diagnosed of multifocal and family history of paraganglioma. Surgery was carried out by median sternotomy and extracorporeal circulation. The pathological examination of the surgical specimen showed a para-aortic low-grade tumor, positive for chromogranin and synaptophysin, cytokeratin AE1-AE3 negative and Ki67 lower than 5%, compatible with paraganglioma. Currently, the patient is tumor free, under clinical monitoring. Conclusions: 111In- Pentetreotide scan proved to be a helpful diagnostic method because of its potential to explore full body, so It allows us to locate unsuspected and atypical location paragangliomas. This finding suggests that patients diagnosed with multifocal head and neck paraganglioma should undergo periodical follow-up with 111In-Pentetreotide scan to detect unsuspected paraganglioma.

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