Monitorización de digoxina en pacientes ancianos

  1. HERNÁNDEZ IGLESIAS, Camino 1
  2. García González, David
  3. PÉREZ BLANCO, Jonás Samuel 1
  4. MARTÍN SUÁREZ, Ana María 3
  1. 1 Universidad de Salamanca
    info

    Universidad de Salamanca

    Salamanca, España

    ROR https://ror.org/02f40zc51

  2. 2 IBSAL (Instituto de Investigación Biomédica de Salamanca) Complejo Asistencial Universitario de Salamanca. Hospital Virgen de la Vega,
  3. 3 Departamento de Ciencias Farmacéuticas. Facultad de Farmacia, Salamanca
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Journal:
Farmajournal

ISSN: 2445-1355

Year of publication: 2017

Volume: 2

Issue: 1

Pages: 21-29

Type: Article

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More publications in: Farmajournal

Abstract

Digoxin is a frequently prescribed drug in the elderly population. Estimated glomerular filtration rate is used to adjust dosages. The HUGE value is a tool for differentiating the presence or absence of chronic kidney disease in elderly patients. The objective was to investigate the usefulness of an equation based on the HUGE value: C= 0,281+0,029 x HUGE + 5, 38 x Dose to predict the initial dose of digoxin in patients older than 70 years. This equation was validated retrospectively (33 patients) and prospectively (35 patients) in comparison with the PKS® method (Pharmacokinetic System, Abbott) based on creatinine clearance. The predictive performance of our equation was better than that obtained with the compared method.In conclusion, clinical validity and superiority of an equation based on the HUGE value is presented. Our results support the need to perform digoxin dosing in elderly people bearing in mind the changes in renal physiology secondary to ageing and not merely the estimated glomerular filtration rate.

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