Genetic characterization of cdk1 in mouse development and homeostasis; A novel dichotomy between stem and committed mitotic cell cycles

  1. Symonds, Catherine Evangeline
Dirigée par:
  1. Mariano Barbacid Montalbán Directeur/trice
  2. David Santamaría Velilla Co-directeur

Université de défendre: Universidad Autónoma de Madrid

Fecha de defensa: 16 juillet 2015

Jury:
  1. Manuel Serrano Marugán President
  2. Marcos Malumbres Secrétaire
  3. Ángel Rodríguez Nebreda Rapporteur
  4. Javier León Serrano Rapporteur
  5. Sergio Moreno Pérez Rapporteur

Type: Thèses

Teseo: 394890 DIALNET lock_openBiblos-e Archivo editor

Résumé

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle progression and transcription control. For this reason, CDKs have long been considered attractive therapeutic targets to treat hyperproliferative diseases such as cancer. Yet, the number of Cdks has significantly increased during evolution. My laboratory han been implicated in the genetic characterization of the CDK family with the aim of identifying essential and redundant functions among the diferente members. (extracto del informe del doctor D. Mariano Barbacid Montalbán).