Melanoma uveal: características clínicas, tratamiento y supervivencia en una serie de 500 pacientes
- Vicente, N.
- Saornil Álvarez, María Antonia
- García Álvarez, Ciro
- Almaraz Gómez, Ana
- Alonso Martínez, Pilar
- Frutos Baraja, Jesús
- López-Lara Martín, Francisco
ISSN: 0365-6691
Year of publication: 2013
Volume: 88
Issue: 11
Pages: 433-438
Type: Article
More publications in: Archivos de la Sociedad Española de Oftalmologia
Abstract
Objective To analyse the clinical features, treatment and survival of uveal melanoma patients diagnosed in a referral Intraocular Tumours Unit over a twenty-year period. Methodology A prospective study was performed including five hundred patients, diagnosed between January 1992 and December 2011. Clinical tumour characteristics and treatment were collected in a database in Microsoft@ Access@. The numeric variables were expressed as means of frequency and standard deviation, and the quantitative variables using frequency tables. Results The mean age of the sample was 62.19 years, with 51.2% females, and 64.2% presented with symptoms. The tumours were small in 31.12% of cases, and large in 23.09%, according to COMS criteria. Hazel green was the iris colour in 42.2% of the cases. The initial treatment was episcleral brachytherapy in 42.4% of the total. The overall mortality rate was 17% and 31.3%, and melanoma-related mortality rate was 11.6% and 14.8%, at 5 and 10 years, respectively. Conclusions In the serie studied melanomas were more frequent in women, and a higher proportion of darker irides were observed than in other previous studies. Most of the tumours were diagnosed when they became symptomatic and in the early or medium stages, allowing conservative therapies to be used, with brachytherapy being the predominant treatment. The melanoma-related mortality appeared to be lower than previously data published. However, further studies are required on the factors influencing survival.