Heterotopia de sustancia gris en 2 casos de primeros episodios psicóticos
- Joana Isabel Gonçalves Cerejeira
- Oscar Martin Santiago
- Pilar del Valle López
ISSN: 1134-5934
Ano de publicación: 2021
Volume: 28
Número: 3
Tipo: Artigo
Outras publicacións en: Psiquiatría biológica: Publicación oficial de la Sociedad Española de Psiquiatría Biológica
Resumo
Schizophrenia is associated with certain structural brain alterations, some of them very rare, such as periventricular grey matter heterotopia. It consists of the presence of ectopic grey matter foci and results from a defect in neuronal migration towards the cerebral cortex during neurodevelopment. We present the cases of 2 patients with a family history of psychotic disorders diagnosed of First Episode Psychosis. In both patients, periventricular grey matter foci were found through brain MRI. Both cases show that early brain abnormalities may be involved in the pathogenesis of schizophrenia and these findings support the neurodevelopmental model.