Caracterización fisiopatológica e identificación de biomarcadores de la cronificación del daño renal

Abstract

HYPOTHESIS AND AIMS We hypothesized that the generation of a new in vivo experimental model of transition from AKI to CKD would allow, on the one hand, to search for new urinary markers in the phases prior to the development of CKD that could be used to monitor patients with previous AKI and reduce their risk of developing CKD. On the other hand, we hypothesized that this model would be useful to study the initial period of CKD development to monitor its progression and evolution. Therefore, in this work, we propose the following objectives: 1) To generate an in vivo experimental model of transition from AKI to progressive CKD by applying repeated episodes of AKI. 2) To identify urinary biomarkers capable of monitoring the period after AKI and to follow the progression of CKD. RESULTS We generated a new in vivo experimental model of transition from AKI to CKD. We identified different urinary biomarkers capable of monitoring the period after AKI.