Seizures and COVID-19: Results from the Spanish Society of Neurology’s COVID-19 registry

  1. Fernández, Santiago Fernández 1
  2. Pérez Sánchez, Javier Ricardo 2
  3. Pérez, Guillermo Hernández 3
  4. Pérez, María Rabasa 4
  5. Castro, Cristina Guijarro 56
  6. García-Azorín, David
  7. Ezpeleta, David 7
  1. 1 Hospital Clinic Barcelona
    info

    Hospital Clinic Barcelona

    Barcelona, España

    ROR https://ror.org/02a2kzf50

  2. 2 Hospital General Universitario Gregorio Marañón
    info

    Hospital General Universitario Gregorio Marañón

    Madrid, España

    ROR https://ror.org/0111es613

  3. 3 Hospital Universitari de Bellvitge
    info

    Hospital Universitari de Bellvitge

    l'Hospitalet de Llobregat, España

    ROR https://ror.org/00epner96

  4. 4 Hospital de Fuenlabrada
    info

    Hospital de Fuenlabrada

    Fuenlabrada, España

    ROR https://ror.org/04scbtr44

  5. 5 Hospital Universitario HM Puerta del Sur
    info

    Hospital Universitario HM Puerta del Sur

    Móstoles, España

    ROR https://ror.org/03rk6g530

  6. 6 Hospital Universitario de Valladolid
    info

    Hospital Universitario de Valladolid

    Valladolid, España

    ROR https://ror.org/04fffmj41

  7. 7 Hospital Universitario Quirónsalud Madrid
    info

    Hospital Universitario Quirónsalud Madrid

    Madrid, España

    ROR https://ror.org/018q88z15

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Revista:
Journal of Clinical Neuroscience

ISSN: 0967-5868

Any de publicació: 2022

Volum: 101

Pàgines: 112-117

Tipus: Article

DOI: 10.1016/J.JOCN.2022.05.013 GOOGLE SCHOLAR lock_openAccés obert editor

Altres publicacions en: Journal of Clinical Neuroscience

Objectius de Desenvolupament Sostenible

Resum

We describe a series of patients with COVID-19 who presented with seizures, reported in the Spanish Society of Neurology’s COVID-19 Registry.This observational, descriptive, multicentre, registry-based study includes patients with confirmed COVID-19 who experienced seizures during active infection. We describe the clinical presentation of COVID-19, seizures, and results of complementary tests. We also describe the suspected aetiology of the seizures.Of 232 reported cases, 26 (11.2%) presented with seizures; 7 of these patients (26.9%) had prior history of epilepsy, whereas the remaining 19 (73.1%) had no history of seizures. In most cases, seizures presented on days 0 and 7 after onset of COVID-19. By seizure type, 8 patients (30.7%) presented generalised tonic-clonic seizures, 7 (26.9%) status epilepticus, 8 (30.7%) focal impaired-awareness seizures, and 4 (11.7%) secondary generalised seizures. Six patients (23.1%) also presented other neurological symptoms, including altered mental status and decreased level of consciousness. Predisposing factors for seizures (eg, dementia, tumour, cerebrovascular disease) were observed in 10 of the 19 patients with no prior history of epilepsy (52.6%).Patients with COVID-19 may present with seizures over the course of the disease, either alone or in the context of encephalopathy. Seizures may present in patients with no prior history of epilepsy; however, most of these patients present predisposing factors.

Referències bibliogràfiques

  • Huang, (2020), Lancet, 395, pp. 497, 10.1016/S0140-6736(20)30183-5
  • Romero-Sánchez, (2020), Neurology, 95, pp. e1060, 10.1212/WNL.0000000000009937
  • Helms, (2020), N Engl J Med, 382, pp. 2268, 10.1056/NEJMc2008597
  • Ellul, (2020), Lancet Neurol, 19, pp. 767, 10.1016/S1474-4422(20)30221-0
  • Chen X, Laurent S, Onur OA, et al. A systematic review of neurological symptoms and complications of COVID-19 [published online ahead of print, 2020 Jul 20].J Neurol. 2020;1-11. doi:10.1007/s00415-020-10067.
  • Chuang, (2021), Acta Neurol Scand, 143, pp. 569, 10.1111/ane.13399
  • Kuroda, (2021), Epilepsy Behav, 116, pp. 107785, 10.1016/j.yebeh.2021.107785
  • García-Azorín, (2020), J Neurol Sci
  • https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCovChina/documentos/COVID19_Estrategia_vigilancia_y_control_e_indicadores.pdf.
  • Metlay, (2019), J Respir Crit Care Med, 200, pp. e45, 10.1164/rccm.201908-1581ST
  • Fisher, (2017), Epilepsia, 58, pp. 522, 10.1111/epi.13670
  • Sun, (2021), Int J Infectious Diseases, 103, pp. 647, 10.1016/j.ijid.2020.09.1475
  • Anand, (2020), Epilepsy Behav, 112, pp. 107335, 10.1016/j.yebeh.2020.107335
  • Abdulsalam, (2020), Acta Neurol Scand, 142, pp. 297, 10.1111/ane.13321
  • Lyons, (2020), Seizure, 80, pp. 113, 10.1016/j.seizure.2020.06.010
  • Vohora D, Jain S, Tripathi M, Potschka H. COVID-19 and seizures: Is there a link? Epilepsia. 2020 Sep 17:10.1111/epi.16656. doi: 10.1111/epi.16656. Epub ahead of print. PMID: 32944929; PMCID: PMC7537056.
  • Sen, (2020), Lancet, 395, pp. 735, 10.1016/S0140-6736(19)33064-8
  • Asadi-Pooya, (2020), Seizure, 79, pp. 49, 10.1016/j.seizure.2020.05.005
  • Asadi-Pooya AA, Simani L, Shahisavandi M, Barzegar Z. COVID-19, de novo seizures, and epilepsy: a systematic review. Neurol Sci. 2020 Nov 25:1–17. doi: 10.1007/s10072-020-04932-2. Epub ahead of print. PMID: 33237493; PMCID: PMC7686454.
  • Besnard, (2020), Front Neurol, 26
  • Galanopoulou, (2020), Epilepsia Open, 5, pp. 314, 10.1002/epi4.12399
  • Chen, (2020), Seizure, 81, pp. 198, 10.1016/j.seizure.2020.08.022
  • Moriguchi, (2020), Int J Infectious Diseases, 94, pp. 55, 10.1016/j.ijid.2020.03.062
  • Huang, (2020), Brain Behav Immun, 87, pp. 149, 10.1016/j.bbi.2020.05.012
  • Zhou, (2020), J Neurol, 267, pp. 2179, 10.1007/s00415-020-09929-7
  • Frontera JA, Sabadia S, Lalchan R, Fang T, Flusty B, Millar-Vernetti P, Snyder T, Berger S, Yang D, Granger A, Morgan N, Patel P, Gutman J, Melmed K, Agarwal S, Bokhari M, Andino A, Valdes E, Omari M, Kvernland A, Lillemoe K, Chou SH, McNett M, Helbok R, Mainali S, Fink EL, Robertson C, Schober M, Suarez JI, Ziai W, Menon D, Friedman D, Friedman D, Holmes M, Huang J, Thawani S, Howard J, Abou-Fayssal N, Krieger P, Lewis A, Lord AS, Zhou T, Kahn DE, Czeisler BM, Torres J, Yaghi S, Ishida K, Scher E, de Havenon A, Placantonakis D, Liu M, Wisniewski T, Troxel AB, Balcer L, Galetta S. A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City. Neurology. 2020 Oct 5:10.1212/WNL.0000000000010979. doi: 10.1212/WNL.0000000000010979. Epub ahead of print. PMID: 33020166.
  • Lu, (2020), Epilepsia, 61, 10.1111/epi.16524
  • Xiong W, Mu J, Guo J, et al. New onset neurologic events in people with COVID-19 infection in three regions in China [published online ahead of print, 2020 Jun 17].Neurology. 2020;10.1212/WNL.0000000000010034. doi:10.1212/WNL.0000000000010034.
  • Hepburn, (2021), Neurocrit Care, 34, pp. 139, 10.1007/s12028-020-01006-1
  • Huang, (2020), Epilepsia, 61, pp. 1884, 10.1111/epi.16635
  • Fonseca, (2020), Acta Neurol Scand, 142, pp. 545, 10.1111/ane.13335
  • Sanchez-Larsen, (2020), Epilepsy Behav, 112, pp. 107396, 10.1016/j.yebeh.2020.107396
  • Conde Blanco E, Manzanares I, Centeno M, Khawaja M, Betrán O, Donaire A, Carreño M. Epilepsy and lockdown: A survey of patients normally attending a Spanish centre. Acta Neurol Scand. 2020 Sep 29:10.1111/ane.13354. doi: 10.1111/ane.13354. Epub ahead of print. PMID: 32990951; PMCID: PMC7646661.