Design, Synthesis and Biological Evaluation of Benzodiazepines Analogues as Anti-Tubuling Agents
- Pilar Puebla 12
- Rafael Peláez 12
- Manuel Medarde 12
- Raquel Álvarez 12
- Myriam González 12
- Alba Vicente 12
- 1 Dpto Ciencias Farmacéuticas. Facultad de Farmacia. Universidad de Salamanca.
- 2 Campus Miguel de Unamuno. 37007. Salamanca
ISSN: 2445-1355
Année de publication: 2019
Type: Article
D'autres publications dans: FarmaJournal
Résumé
The naturally occurring combretastatin (CA-4) and its analogue phenstatinare interesting molecules in medicinal chemistry (Figure 1, I), they block thepolymerization of tubulin, interacting with the colchicine binding site, and thiscompounds have displayed a high degree of cytotoxicity on several cancer cell lines.