Prolinamides as Asymmetric Organocatalysts

  1. Pedrosa Sáez, Rafael
  2. Andrés García, José María
Livre:
Sustainable Catalysis: Without Metals or Other Endangered Elements

Éditorial: Royal Society of Chemistry

ISBN: 978-1-78262-209-3

Année de publication: 2015

Pages: 120-139

Type: Chapitre d'ouvrage

DOI: 10.1039/9781782622093-00120 GOOGLE SCHOLAR lock_openUVADOC editor

Résumé

Prolinamides are valuable organocatalysts for enantioselective transformations that occur by activation of the nucleophile by enamine formation. Different substituents can be appended on the nitrogen atom of the carboxamide, which allow for the modulation of the catalytic properties. In that way, the acidity, the hydrogen donor properties, the hydrophobicity, or the chiral environment can be modified, in a few steps, starting from easily available proline.

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