Methylamine Activates Glucose Uptake in Human Adipocytes Without Overpassing Action of Insulin or Stimulating its Secretion in Pancreatic Islets

  1. Christian Carpéné 12
  2. Pascale Mauriège 3
  3. Nathalie Boulet 12
  4. Simon Biron 3
  5. Jean-Louis Grolleau 4
  6. Maria José Garcia-Barrado 567
  7. Mari Carmen Iglesias-Osma 567
  1. 1 French Institute of Health and Medical Research
    info

    French Institute of Health and Medical Research

    París, Francia

    ROR https://ror.org/02vjkv261

  2. 2 Université de Toulouse
    info

    Université de Toulouse

    Tolosa, Francia

  3. 3 Laval University
    info

    Laval University

    Quebec, Canadá

    ROR https://ror.org/04sjchr03

  4. 4 Hôpital Rangueil
    info

    Hôpital Rangueil

    Tolosa, Francia

    ROR https://ror.org/034zn5b34

  5. 5 Instituto de Neurociencias de Castilla y León
    info

    Instituto de Neurociencias de Castilla y León

    Salamanca, España

  6. 6 Instituto de Investigación Biomédica de Salamanca
    info

    Instituto de Investigación Biomédica de Salamanca

    Salamanca, España

    ROR https://ror.org/03em6xj44

  7. 7 Universidad de Salamanca
    info

    Universidad de Salamanca

    Salamanca, España

    ROR https://ror.org/02f40zc51

Erakutsi afiliazioak +
Aldizkaria:
Medicines

ISSN: 2305-6320

Argitalpen urtea: 2019

Alea: 6

Zenbakia: 3

Orrialdeak: 89

Mota: Artikulua

DOI: 10.3390/MEDICINES6030089 GOOGLE SCHOLAR lock_openSarbide irekia editor

Beste argitalpen batzuk: Medicines

Garapen Iraunkorreko Helburuak

Laburpena

Methylamine, a natural soluble amine present in foods, is known to be asubstrate of primary amine oxidase (PrAO) widely expressed in animal tissues. Methylamine hasbeen reported to activate glucose transport in fat cells and to facilitate glucose disposal in rabbits butthe interests and limits of such insulin-mimicking actions have not been further explored. This workaimed to perform a preclinical study of the inter-individual variations of these biological propertiesto study the putative link between PrAO activity and insulin resistance. Methods: Methylamine wastested on human adipocyte preparations and in rabbit pancreatic islets to determine its influenceon glucose uptake and insulin release, respectively. PrAO activity and related responses weredetermined in adipose tissues obtained from two cohorts of non-obese and obese women. Results:Adipose tissue PrAO activity was negatively correlated with insulin resistance in high-risk obesewomen. PrAO-dependent activation of glucose uptake was negatively correlated with body massindex and reflected the decrease of insulin responsiveness of human fat cells with increasing obesity.Methylamine exhibited antilipolytic properties in adipocytes but was unable to directly activateinsulin secretion in isolated pancreatic islets. Conclusions: PrAO activation by its substrates, e.g.,methylamine, increases glucose utilization in human adipocytes in a manner that is linked to insulinresponsiveness. Methylamine/PrAO interaction can therefore contribute to adipose tissue enlargementbut should be considered as potentially useful for diabetes prevention since it could limit lipotoxicityand facilitate glucose handling, at the expense of favoring healthy fat accumulation.

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