Altered gamma band noise power in schizophrenia and bipolar patients during a cognitive task

  1. Benjamín Cea-Cañas 1
  2. Álvaro Díez 2
  3. Alba Lubeiro 3
  4. María Iglesias 4
  5. Carmen Capella 5
  6. Alberto Rodríguez-Lorenzana 6
  7. Vicente Molina 7
  1. 1 Clinical Neurophysiology Service. Clinical Hospital of Valladolid. Valladolid. Spaina
  2. 2 Psychiatry Department, School of Medicine, University of Valladolid. Valladolid. Spain
  3. 3 Psychiatry Department, School of Medicine, University of Valladolid. Valladolid. España
  4. 4 Clinical Neurophysiology Service. Clinical Hospital of Valladolid. Valladolid. Spain
  5. 5 Psychiatry Service, Clinical Hospital of Valladolid. Valladolid. Spain
  6. 6 School of Psychology, Universidad de Las Américas, Quito, Ecuador
  7. 7 Neurosciences Institute of Castilla y León (INCYL), School of Medicine, University of Valladolid/ Psychiatry Service, Clinical Hospital of Valladolid/ Psychiatry Department, School of Medicine, University of Valladolid. Valladolid. Spain
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Revue:
European journal of psychiatry

ISSN: 0213-6163

Année de publication: 2021

Volumen: 35

Número: 3

Pages: 129-139

Type: Article

DOI: 10.1016/J.EJPSY.2020.11.003 DIALNET GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: European journal of psychiatry

Objectifs de Développement Durable

Résumé

Background and Objectives: “Noise power” (NP) is a measure that allows the assessment of the fast-firing synchronization of neural oscillations. We aimed to replicate higher gamma NP values in frontal and midline regions in patients with schizophrenia and re-evaluate its specificity to this disorder. We also aimed to assess the relationship of higher gamma NP values with drug treatment, chronicity, cognition and symptoms. Methods: Gamma NP values were obtained from electroencephalograms recorded during an oddball paradigm from 29 patients with schizophrenia, 27 with bipolar disorder and 36 healthy controls. We compared these values between the groups to evaluate the specificity to diagnosis. Altered gamma NP values were compared between the patients who had and had not received different treatments to assess the relationship with drug treatment. We also analyse the correlation between gamma NP values and chronicity, symptoms, and cognition. Results. Compared to controls, patients with schizophrenia presented increased gamma NP values in frontal and parietal midline regions, while bipolar patients showed increased gamma NP in the left frontal region. There was no significant relationship between drug treatment or chronicity with altered values. Increased gamma NP correlated with higher negative symptom scores in the schizophrenia group, but not with cognitive impairment in any of the groups of patients. Conclusions: We replicated an increase in gamma NP in patients with schizophrenia and found that this alteration was also present in a milder form in bipolar patients. These alterations seem to be independent of pharmacological treatment and illness duration.

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Information sur le financement

This work has been supported by the following grants: the “Instituto de Salud Carlos III” (PI18/00178), the “Gerencia Regional de Salud de Castilla y León” (GRS 1485/A/17 and GRS 1721/A/18), and the “Consejería de Educación de la Junta de Castilla y León” (VA057P17).

Financeurs

La source de données: Dialnet