Eficacia y efectos adversos del tratamiento con Imiquimod en la mujer con condilomas vulvoperineales

  1. Ángel García Iglesias 1
  2. Silvia García Valle 1
  3. Miguel Gauro 1
  4. Joaquín López Marcos 1
  5. Tomás Rodríguez Bravo 1
  6. Consuelo Crespo Martínez 1
  7. Rafael Collazos Robles 1
  1. 1 Departamentos de Obstetricia y Ginecología, Farmacia y Cirugía. Facultad de Medicina y Hospital Clínico Universitario
Journal:
Revista Electrónica de Biomedicina

ISSN: 1697-090X

Year of publication: 2010

Issue: 3

Pages: 34-41

Type: Article

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Abstract

The genital warts constitute a benign process which appears on young people and it is produced by the HPV. In the course of several years different technics have been used with the goal of settling these kinds of lesions in a fast and safe way. Aim: To assess the response of the treatment of vulvo-perineal condylomas treated with 5% Imiquimod and the adverse events arised from its use. Material and methods: The studied population is constituted by 112 patients who presented vulvo-perineal condylomas. Pregnant and HIV positive patients were not included. All of them underwent a complete gynecological study and specifically, cytology, colposcopy, a PCR for HPV and a vulvoscopy to assess the location of the condylomas, size and number of such. Lesions were treated with Imiquimod 5% in cream at alternate nights. Tests were carried out to verify the results of the treatment at 4, 8, 12 and 16 weeks. The maximum time of application was 16 weeks. Results: The multiple locations were the most common, followed by those ones of the perineal area and the ano-fourchette. The disappearance of condylomas occurred in the highest percentage between 4 and 8 weeks of treatment, and 3 months later no lesions were 88.8%. 87,5% had no lesions at 6 months.The most common side effects were erythema and pruritus. Conclusions: In view of the results, the treatment with 5% Imiquimod can be considered as an alternative to other destructive therapies, which in turn, acts on the latent infection.

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