El enzima indoleamina 2,3 dioxigenasa ((IDO) y la tolerancia inmune

  1. María Jesús Coma-del-Corral 1
  2. Pilar Muñiz Rodríguez 2
  3. Joaquín Terán Santos 3
  1. 1 Unidad de Investigación del Hospital Universitario de Burgos
  2. 2 Departamento de Biología y Bioquímica molecular de la Universidad de Burgos
  3. 3 Unidad de Sueño del Hospital Universitario de Burgos.
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Journal:
Revista Electrónica de Biomedicina

ISSN: 1697-090X

Year of publication: 2013

Issue: 3

Pages: 47-58

Type: Article

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Abstract

Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme and extrahepatic predominantly found in many cells, especially macrophages. Tryptophan degradation generates kynurenine, and this pathway of tryptophan metabolism is an effective mechanism for modulating the immune response. The IDO facilitates immune tolerance and is one of the main actors involved in the inhibition of cell proliferation, including activated T cells. The IDO induces production of reactive oxygen species (ROS) and nitric radicals (NO) oxide. Several pathways involved in the regulation of immune response are regulated by redox mechanisms. Reactive oxygen and nitrogen species (ROSRNS) and other redox active molecules play key roles in immunity.

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