Formulación y optimización de nanopartículas lipídicas con chitosán para la administración de quercetina

  1. Gallego, Diego 1
  2. Colino, Clara Isabel 1
  1. 1 Universidad de Salamanca
    info

    Universidad de Salamanca

    Salamanca, España

    ROR https://ror.org/02f40zc51

Journal:
Farmajournal

ISSN: 2445-1355

Year of publication: 2023

Volume: 8

Issue: 2

Pages: 17-25

Type: Article

DOI: 10.14201/FJ2023821725 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Farmajournal

Abstract

Quercetin presents numerous activities, such as antioxidant, anticancer,  cardioprotective, etc. that make it suitable for its therapeutic use. However, quercetin has a limited biodisponibility due to its low water solubility which limits its pharmaceutical application. In this work, the encapsulation of quercetin in chitosan-coated liposomes was proposed. The influence of the molecular weight of chitosan (ultralow, low and medium) and phosphatidylcholine:chitosan ratio (16:1, 8:1, 4:1) on the size, polydispersity index, encapsulation efficiency and zeta potential of the prepared nanoparticles were evaluated, obtaining values of 339.02-670.62 nm, 0,26 y 0,32, 43.5-59.3 % y 55.2-63.3 mV respectively. Subsequently, low molecular weight chitosan and phosphatidylcholine:chitosan 16:1 ratio were selected for a freeze-drying study of the nanoparticles, with freezing temperatures of -20 ºC and -80 ºC and lactose, trehalose and sucrose as cryoprotectants. The encapsulation efficiency and residual moisture were studied. Freezing conditions at -80 ºC and trehalose as cryoprotectant prevented the loss of encapsulated quercetin to a greater extent.

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