Actividad antioxidante de metabolitos de flavonoides originados por la microflora del intestino humano

  1. Felipe Surco-Laos 1
  2. Manuel Valle Campos 1
  3. Eddie Loyola 1
  4. Montserrat Dueñas 2
  5. Celestino Santos 2
  1. 1 Universidad San Luis Gonzaga de Ica Facultad de Farmacia y Bioquímica
  2. 2 Universidad de Salamanca Grupo de Investigación de Polifenoles
Journal:
Revista de la Sociedad Química del Perú

ISSN: 2309-8740,  1810-634X

Year of publication: 2016

Volume: 82

Issue: 1

Pages: 29-37

Type: Article

DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Revista de la Sociedad Química del Perú

Abstract

Flavonoids and more phenolic compounds when ingested are metabolized to phenolic acids, which are classified as benzoic, phenylacetic and cinnamic primarily, by "in vitro" methods (ABTS and FRAP), the antioxidant capacity of phenolic acids of potential metabolic interest was determined. The values vary by chemical reaction involved and the structure of the compounds, which influences the number of radicals, their position on the benzene ring relative to the carboxylic group and the chain length of the latter. In interactions between mixtures of acids a mainly antagonistic effect is observed, there is no structural pattern that explains it.

Bibliographic References

  • Aura, AM. (2002). O`Leary KA.Willianson G.Ojala M.Bailey M.Puupponen-Pimia R Quercetin derivatives are deconjugayed and converted to hydroxyphenylacetic acids but not methylated by Human Fecal flora in vitro. J Agri Food Chem. 50. 17225
  • Déprez, S,Brezillon, C,Rabot, S,Philippe, C,Mila, I,Lapierre, C. (2000). Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular weight phenolic acids. J Nutr. 130. 2733-2738
  • Lambert, JD,Sang, S,Yang, CS. (2007). Biotransformation of Green Tea Polyphenols and the Biological Activities of those Metabolites. Mol Pharm. 4. 819
  • Prior, RL,Wu, X,Schaich, K. (2005). Standardized methods for the determination of antioxidant capacity and phenolic in foods and dietary supplements. J Agric Food Chem. 53. 4290-4302
  • Hollman, PC,Katan, MB. (1997). Absorption, Metabolism and health of dietary flavonoids in man. Biomed Pharmacother. 51. 305-310
  • Al-Farsi, M,Alasalvar, C,Morris, A,Baron, M,Shahidi, F. (2005). Comparison of antioxidant activity anthocyanins, carotenoids, and phenolic of three native fresh and sun-dried date (Phoenix dactylifera) varieties grown in Oman. J Agric Food Chem. 53. 75927599
  • Huang, D,Ou, B,Prior, RL. (2005). The Chemistry behind Antioxidant Capacity Assays. J Agric Food Chem. 53. 1841-1856
  • Rice-Evans, C,Miller, N,Paganga, G. (1996). Structure-antioxidant activity relationship of flavonoids and Phenolic acid. Free Radic Biol Med. 20. 933-956
  • Lee, HC,Jenner, AM,Low, CS,Lee, YK. (2006). Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Res Microbiol. 157. 876
  • Benzie, I,Strain, J. (1999). Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol. 299. 15-27
  • Re, R,Pellegrini, N,Proteggente, A,Pannala, A,Yang, M,Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 26. 1231
  • Frankel, E,Meyer, A. (2000). The problems of using one-dimensional methods to evaluate multifunctional food and biological antioxidants. J Sci Food Agric. 80. 1925
  • Chen, JW,Zhu, ZQ,Hu, TX,Zhu, DY. (2002). Structure-activity relationship of natural flavonoids in hydroxyl radical-scavenging effects. Acta Pharmacol Sin. 23. 667
Data source: Dialnet