Síntesis de heterociclos nitrogenados complejos mediante secuencias Ugi/reacciones de post-condensación radicalarias y/o polares

Abstract

In the Phd thesis Synthesis of complex nitrogenous heterocycles by Ugi sequences/ radical and/or polar post-condensation reactions, the synthesis of heterocyclic nitrogenous compounds with complex structures, many of them privileged structures, widely used in the pharmaceutical industry, such as lactams or hydantoins, is described. Usually, the synthesis of many of these compounds requires numerous steps, which makes them unattractive for the industry. In this work, by using multicomponent reactions such as the Ugi reaction, followed by radical or polar post-condensation reactions, it has been possible to obtain these complex heterocycles in only two reaction steps, with high yields and using mild reaction conditions. Moreover, in some cases, enantioselective synthesis of these products has been achieved employing this synthetic procedure.