GALLO: An R package for Genomic Annotation and integration of multiple data source in livestock for positional candidate LOci

Resumo

The development of high-throughput sequencing and genotyping methodologies allowed the identification of thousands of genomic regions associated with several complex traits. The integration of multiple sources of biological information is a crucial step required to better understand patterns regulating the development of these traits. Genomic Annotation in Livestock for positional candidate LOci (GALLO) is an R package developed for the accurate annotation of genes and quantitative trait loci (QTLs) located in regions identified in common genomic analyses performed in livestock, such as Genome-Wide Association Studies and transcriptomics using RNA-Sequencing. Moreover, GALLO allows the graphical visualization of gene and QTL annotation results, data comparison among different grouping factors (e.g., methods, breeds, tissues, statistical models, studies, etc.), and QTL enrichment in different livestock species including cattle, pigs, sheep, and chickens, etc. Consequently, GALLO is a useful package for the annotation, identification of hidden patterns across datasets, datamining previously reported associations, as well as the efficient scrutinization of the genetic architecture of complex traits in livestock.