The polymodal ion cahnnel trpc6 is present in meissner corpuscles co-expressed with trpv4

  1. R. Cabo 1
  2. P. López 1
  3. I. San José 2
  4. F. Pastor 2
  5. A. Gago 1
  6. G. Vázquez 1
  7. R. Cobo 1
  8. O. García-Suárez 1
  9. J.A. Vega 1
  1. 1 Universidad de Oviedo
    info

    Universidad de Oviedo

    Oviedo, España

    ROR https://ror.org/006gksa02

  2. 2 Universidad de Valladolid
    info

    Universidad de Valladolid

    Valladolid, España

    ROR https://ror.org/01fvbaw18

Proceedings:
XXVII CONGRESS OF THE SPANISH ANATOMICAL SOCIETY

ISSN: 1136-4890,  2340-311X

Year of publication: 2015

Volume: 19

Issue: S2

Pages: 13

Congress: XXVII CONGRESS OF THE SPANISH ANATOMICAL SOCIETY

Type: Conference paper

GOOGLE SCHOLAR lock_openOpen access editor

Abstract

The mechanoreceptors are the places where theprocess of transformation of the mechanical im-pulses into electric signal takes place. Consistentlysome types of mechanoreceptors, both in verte-brates and not vertebrates, express potentialmechanoproteins directly involved in the mecha-notransduction. Among putative mechanoproteinsare some ion channels belonging to TRP and Deg/ENa+C families. In this research we have investi-gated using double immunofluorescence the ex-pression of the mechanoproteins TRPC6 (transientreceptor potential canonical 6) and TRPV4(transient receptor potential vaniloid 4) in Meissnercorpuscles of human and Macaca fasciculata gla-brous digital skin. Both TRPC6 and TRPV4 arerelated to the mechanorecepcion, and co-expression of both has been associated to me-chanical algesia. The immunoreactivity for TRPC6and TRPV4 was co-localized with axonal markers,and never with specific markers for lamellar cells,in the axons of Meissner corpuscles, in both spe-cies. In addition, TRPV4 has also axonal localiza-tion, and co-localized with TRPC6. These resultsdemonstrate the presence and co-expression oftwo putative mechanoproteins in Meissner corpus-cles and probably this fact is at the basis of poly-modal role of Meissner corpuscles