Age-dependent changes in the expression of Trkb by human Meissner corpuscles

  1. García-Suárez O 1
  2. Calavia MG 1
  3. Feito J 1
  4. Galvez A 2
  5. Cabo R 1
  6. del Valle ME 1
  7. Vega JA. 11
  1. 1 Universidad de Oviedo
    info

    Universidad de Oviedo

    Oviedo, España

    ROR https://ror.org/006gksa02

  2. 2 Universidad de Castilla-La Mancha
    info

    Universidad de Castilla-La Mancha

    Ciudad Real, España

    ROR https://ror.org/05r78ng12

Actes de conférence:
XXV Congress of the spanish Society of Anatomy

ISSN: 1136-4890,  2340-311X

Année de publication: 2011

Volumen: 15

Número: S1

Pages: 28

Congreso: XXV Congress of the spanish Society of Anatomy

Type: Communication dans un congrès

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Résumé

Unlike other types of sensory corpuscles and nerveendings, which have very complex neuronal and growth fac-tor dependence, the cutaneous Meissner corpuscles dependexclusively on the NT system TrkB/BDNF/NT-4. However,the pattern of expression of TrkB in human Meissner corpus-cles in not known. The experiments in this study were desig-ned to pursue further the findings that suggest that BDNFand NT4 have critical roles in the development and mainte-nance of Meissner corpuscles, by analyzing the pattern ofexpression of TrkB, their high-affinity receptor, in human gla-brous skin at different ages from 8 weeks of life to old sub-jects. In developing Meissner corpuscles TrkB was expressedin the axon supplying the corpuscles (until 18 months of age).Thereafter there was a switch in the localization of TrkBwhich was restricted to the lamellar cells of Meissner corpus-cles. Importantly that the number of Meissner corpuscles thatexpress TrkB significantly decreases in subjects older than 50years. All together these results lend support to the role ofBDNF and NT4 in mechanoreception