A Cu-Catalyzed C-N Bond Coupling Route to Substituted Indazoles

  1. Viña, D. 1
  2. Olmo, E. 12
  3. López-Pérez, J. 1
  4. Feliciano, A. 12
  1. 1 CIETUS, Centro de Investigación de Enfermedades Tropicales
  2. 2 Universidad de Salamanca
    info

    Universidad de Salamanca

    Salamanca, España

    ROR https://ror.org/02f40zc51

Revista:
Synfacts

ISSN: 1861-1958,  1861-194X

Año de publicación: 2007

Año: 2007

Volumen: 4

Páginas: 0360-0360

Tipo: Artículo

DOI: 10.1055/S-2007-968377 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Synfacts

Resumen

A general methodology for the synthesis of indazoles based on a traditional Ullmann reaction is reported. Thus, copper-catalyzed C-N bond coupling of ortho-halo aromatic ketones and carboxylic acids with hydrazines leads to intermediates which undergo dehydration to indazoles in poor to very good yields depending on structural variation. The scope of the reaction was insufficiently investigated