Bioorgánica
BIOORG
R.
Pérez Tomás
Publicaciones en las que colabora con R. Pérez Tomás (19)
2024
2023
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Antimetastatic Properties of Prodigiosin and the BH3-Mimetic Obatoclax (GX15-070) in Melanoma
Pharmaceutics, Vol. 15, Núm. 1
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Small molecule anion carriers facilitate lactate transport in model liposomes and cells
iScience, Vol. 26, Núm. 10
2022
2021
2020
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Click-tambjamines as efficient and tunable bioactive anion transporters
Chemical Communications, Vol. 56, Núm. 21, pp. 3218-3221
2019
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Targeting autophagy for cancer treatment and tumor chemosensitization
Cancers, Vol. 11, Núm. 10
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The natural-based antitumor compound T21 decreases survivin levels through potent stat3 inhibition in lung cancer models
Biomolecules, Vol. 9, Núm. 8
2018
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Small molecule anionophores promote transmembrane anion permeation matching CFTR activity
Scientific Reports, Vol. 8, Núm. 1
2017
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Inhibition of Human Enhancer of Zeste Homolog 2 with Tambjamine Analogs
Journal of Chemical Information and Modeling, Vol. 57, Núm. 8, pp. 2089-2098
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Novel indole-based tambjamine-analogues induce apoptotic lung cancer cell death through p38 mitogen-activated protein kinase activation
Molecular Cancer Therapeutics, Vol. 16, Núm. 7, pp. 1224-1235
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Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and necrotic cell death in lung cancer
Biochemical Pharmacology, Vol. 126, pp. 23-33
2015
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Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells
Journal of the American Chemical Society, Vol. 137, Núm. 50, pp. 15892-15898
2014
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Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs
Organic and Biomolecular Chemistry, Vol. 12, Núm. 11, pp. 1771-1778
2013
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Anion transporters and biological systems
Accounts of Chemical Research, Vol. 46, Núm. 12, pp. 2801-2813
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Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members
PLoS ONE, Vol. 8, Núm. 2
2012
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Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: Prodigiosin vs. obatoclax
Biochemical Pharmacology, Vol. 83, Núm. 4, pp. 489-496
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Tambjamine alkaloids and related synthetic analogs: Efficient transmembrane anion transporters
Chemical Communications, Vol. 48, Núm. 10, pp. 1556-1558
2011
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Synthetic prodiginine obatoclax (GX15-070) and related analogues: Anion binding, transmembrane transport, and cytotoxicity properties
Chemistry - A European Journal, Vol. 17, Núm. 50, pp. 14074-14083