Publications by the researcher in collaboration with Manuel Medarde Agustín (181)

2023

  1. Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy

    Bioorganic Chemistry, Vol. 131

2021

  1. Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 36, Núm. 1, pp. 1029-1047

  2. Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

    European Journal of Medicinal Chemistry, Vol. 209

  3. Microtubule destabilizing sulfonamides as an alternative to taxane-based chemotherapy

    International Journal of Molecular Sciences, Vol. 22, Núm. 4, pp. 1-21

  4. New diarylsulfonamide inhibitors of Leishmania infantum amastigotes

    International Journal for Parasitology: Drugs and Drug Resistance, Vol. 16, pp. 45-64

  5. New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure–activity relationships, and molecular modelling

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 36, Núm. 1, pp. 2025-2044

2020

  1. Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring

    Bioorganic Chemistry, Vol. 98

2019

  1. Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target

    Medicinal Research Reviews, Vol. 39, Núm. 3, pp. 775-830

  2. Design, Synthesis and Biological Evaluation of Benzodiazepines Analogues as Anti-Tubuling Agents

    FarmaJournal

  3. Diseño, síntesis y evaluación de amidas y sulfonamidas con actividad tipo colchicina contra Strongyloides venezuelensis

    XI Congreso de la Sociedad Española de Medicina Tropical y Salud Internacional (SEMTSI)

  4. The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors

    Molecules (Basel, Switzerland), Vol. 24, Núm. 23

2018

  1. Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

    European Journal of Medicinal Chemistry, Vol. 158, pp. 167-183

2016

  1. Pyridine based antitumour compounds acting at the colchicine site

    Current Medicinal Chemistry, Vol. 23, Núm. 11, pp. 1100-1130

2015

  1. Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para -nitrogen substituted isocombretastatins

    European Journal of Medicinal Chemistry, Vol. 100, pp. 210-222

2014

  1. New ligands of the tubulin colchicine site based on X-ray structures

    Current Topics in Medicinal Chemistry, Vol. 14, Núm. 20, pp. 2231-2252

  2. P, p -dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin Inhibition

    Journal of Organic Chemistry, Vol. 79, Núm. 15, pp. 6840-6857

2013

  1. Endowing indole-based tubulin inhibitors with an anchor for derivatization: Highly potent 3-substituted indolephenstatins and indoleisocombretastatins

    Journal of Medicinal Chemistry, Vol. 56, Núm. 7, pp. 2813-2827

2011

  1. New para-para stilbenophanes: Synthesis by mcmurry coupling, conformational analysis and inhibition of tubulin polymerisation

    Chemistry - A European Journal, Vol. 17, Núm. 12, pp. 3406-3419

  2. Synthesis of novel polynitrogenated drugs based on phenstatins. Tubulin polymerization evaluation

    4TH EUROPEAN CONFERENCE ON CHEMISTRY FOR LIFE SCIENCES

2010

  1. Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins

    European Journal of Medicinal Chemistry, Vol. 45, Núm. 2, pp. 588-597