Modulación por las isoformas de Ras de la síntesis de matriz extracelular y proliferación en fibroblastos
- José Miguel López Novoa Zuzendaria
- José Carlos Martínez Salgado Zuzendaria
Defentsa unibertsitatea: Universidad de Salamanca
Fecha de defensa: 2009(e)ko ekaina-(a)k 01
- María Jesús Monte Río Presidentea
- María Nélida Eleno Balboa Idazkaria
- María Piedad Ruiz Torres Kidea
- José Manuel Valdivieso Revilla Kidea
- Octavio Alda Torrubia Kidea
Mota: Tesia
Laburpena
Fibroblasts are the main ECM-producing cells (extracellular matrix), but depending on the type of tissue cell types can appear other residents. The fibroblasts produce large amounts of ECM, inducing the replacement of the usual components of tissue by fibrous material. Knowledge of the molecular mechanisms governing the deposition and degradation of ECM in physiological and pathophysiological conditions may be useful in designing preventive strategies, thereby reducing the progression of these pathological processes that occur with fibrosis