Seroconversión reversa y hepatitis B fulminante en paciente sometida a tratamiento quimioterápico por Linfoma no Hodgkin
- Bécares Lozano, Milagros
- González Román, Jorge
- Jiménez López, Antonio
ISSN: 0304-4866, 1989-3922
Year of publication: 2013
Volume: 74
Issue: 4
Pages: 191-193
Type: Article
More publications in: Galicia Clínica
Sustainable development goals
Abstract
Loss of HBsAg in acute Hepatitis B is a sign of good prognosis, though the virus can remain in the liver in the presence of HBc Ac and low serum levels of HBV DNA. However immunosuppressive therapy can induce viral reactivation in these patients, mainly when rituximab and or corticosteroids are administered ,with subsequent reappearance of HBs Ag (reverse seroconversion). We report a case of a female patient with a B-cell non Hodgkin lymphoma who at the onset of chemotherapy was negative for HBs Ag but positive for both HBs Ac and HBc Ac. Lack of prophylactic treatment with nucleotide/nucleoside analogues allowed the development of acute HBV reactivation and fulminant hepatitis. A review of scientific literature is also ncluded.